Emerging Tech Forum

The Atlantic Nano Forum presents

Applications of Semiconductor-Based DNA MicroArrays in Medicine

with a presentation by Dr. Amit Kumar, President, CEO,

Combimatrix Corporation

Date:	Wednesday, April 26, 2006
Time	Registration begins at 4:00 PM; program begins at 4:30 PM
Cost:	Attendance is free
Location:	Offices of Buchanan Ingersoll & Rooney 1737 King Street Alexandria, VA Please send RSVP to nanotech@bipc.com Directions

Applications of Semiconductor-Based DNA MicroArrays in Medicine

Dr. Amit Kumar will present a platform technology, which combines semiconductor engineering, nanotechnology and molecular biology, to enable a genetic analysis tool with broad medical applications. He will discuss two major and very timely applications: influenza detection and monitoring; as well as personalized treatment for cancer. The H5N1 strain of influenza, known as avian flu, results in 50% mortality in infected humans. If the virus were able to mutate and become communicable while maintaining its pathogenicity, it may cause the greatest pandemic in recorded history. His chip-based analytical tool can identify the specific strain of all known influenza A viruses, provide information on genetic drift, identify newly mutated viruses and provide information on virus sub-strains. product also has broader applicability for other emerging diseases. Through analysis of gene expression in combination with our chip technology, it is now possible to treat cancer patients based on their unique underlying genetics, enabling individual, personalized treatments for cancer patients.

Dr. Amit Kumar President and CEO, Combimatrix Corporation
Dr. Kumar has been president and CEO of CombiMatrix Corporation since September 2001. He has been a director since September 2000. His interest in nanotechnology began with his doctoral studies at Stanford University and the California Institute of Technology, where he studied semiconductor solar cells. After completing his Ph.D., he served as a post-doctoral fellow at Harvard University where, while working with Professor George Whitesides, he was the co-inventor and author of several pioneering patents on a nanotechnology now known as Micro-Contact Printing and Soft Lithography. These patents have been licensed by Fortune 500 companies and younger public and private biotechnology firms. Since that time, Dr. Kumar has worked as a scientist, a venture capitalist and company executive focused on the areas of miniaturization and nanotech. CombiMatrix is commercializing a semiconductor-based array technology that enables the execution of thousands of independent, chemical reactions in parallel in volumes of a few tenths of nanoliters. Commercial applications of this technology include highly parallel genetic analysis microarrays, materials synthesis, drug development and biodefense detection systems. Dr. Kumar sits on a number of private and public company boards and is a board member of the NanoBusiness Alliance and a member of the steering committee of the Washington Nanotechnology Initiative. Dr. Kumar received his bachelors degree in chemistry from Occidental College. After joint studies at Stanford University and the California Institute of Technology, he received his Ph.D. from Caltech in 1991.

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